منابع مشابه
Heat shock protein-peptide complexes for use in vaccines.
The heat shock proteins gp96, HSP70, and HSP90 are complexed to a diverse array of cellular proteins and peptides as a consequence of their chaperone functions. There is good experimental evidence that vaccination with these heat shock protein-peptide complexes elicit immune responses against chaperoned peptide antigens. As shown with gp96, this requires internalization of the heat shock protei...
متن کاملHeat-shock proteins as dendritic cell-targeting vaccines--getting warmer.
Heat-shock proteins (hsp) provide a natural link between innate and adaptive immune responses by combining the ideal properties of antigen carriage (chaperoning), targeting and activation of antigen-presenting cells (APC), including dendritic cells (DC). Targeting is achieved through binding of hsp to distinct cell surface receptors and is followed by antigen internalization, processing and pre...
متن کاملHeat shock proteins and their use as anticancer vaccines.
Giorgio Parmiani, Alessandro Testori, Michele Maio, Chiara Castelli, Licia Rivoltini, Lorenzo Pilla, Filiberto Belli, Vincenzo Mazzaferro, Jorgelina Coppa, Roberto Patuzzo, Mario R. Sertoli, Axel Hoos, Pramod K. Srivastava, and Mario Santinami Istituto Nazionale Tumori and European Institute of Oncology, Milan, Italy; University of Siena, Siena, and Istituto Scientifico Tumori, Genoa, Italy; an...
متن کاملCombination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia.
PURPOSE To test the feasibility, safety, immunogenicity, and clinical efficacy of an autologous vaccine of leukocyte-derived heat shock protein 70-peptide complexes (Hsp70PC), in conjunction with imatinib mesylate, in patients with chronic myeloid leukemia (CML) in chronic phase. EXPERIMENTAL DESIGN Patients had cytogenetic or molecular evidence of disease, despite treatment with imatinib mes...
متن کاملVaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer.
PURPOSE Heat shock proteins (HSP) from tumor cells contain the gp96 polypeptide associated with cancer-specific antigenic peptides. Mice that are immunized with HSP/peptide-complex (HSPPC) derived from cancer tissue reject tumor from which HSPs are purified. We tested in humans whether vaccination with HSPPC-gp96 (Oncophage) from autologous liver metastases of colorectal carcinoma induces cance...
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ژورنال
عنوان ژورنال: Human Vaccines & Immunotherapeutics
سال: 2013
ISSN: 2164-5515,2164-554X
DOI: 10.4161/hv.22652